ORAL CANCER INDUCED TRPV1 SENSITIZATION IS MEDIATED BY PAR2 SIGNALING IN PRIMARY AFFERENT NEURONS INNERVATING THE CANCER MICROENVIRONMENT

Oral cancer induced TRPV1 sensitization is mediated by PAR2 signaling in primary afferent neurons innervating the cancer microenvironment

Abstract Oral cancer patients report sensitivity to spicy foods and liquids.The mechanism responsible for chemosensitivity induced by oral cancer is not known.We simulate oral cancer-induced chemosensitivity in a xenograft oral cancer mouse model using two-bottle choice drinking and conditioned place aversion assays.An anatomic basis of chemosensit

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Alterations in the Levels of Growth Factors in Adolescents with Major Depressive Disorder: A Longitudinal Study during the Treatment with Fluoxetine

Major depressive disorder (MDD) has a prevalence of 5% in adolescents.Several studies have described the association between the inflammatory response and MDD, but little is known about the relationship between MDD and growth factors, such as IL-7, IL-9, IL-17A, VEGF, basic FGF, G-CSF, and GM-CSF.It must be appointed that there are scarce reports o

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